General Information

  • ID:  hor005152
  • Uniprot ID:  P0DMD6
  • Protein name:  Natriuretic peptide TsNP
  • Gene name:  NA
  • Organism:  Tityus serrulatus (Brazilian scorpion)
  • Family:  natriuretic peptide family
  • Source:  animal
  • Expression:  Expressed by the venom gland.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tityus (genus), Buthidae (family), Buthoidea (superfamily), Buthida (parvorder), Scorpiones (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0090729 toxin activity
  • GO BP:  GO:0007165 signal transduction; GO:0008217 regulation of blood pressure; GO:0035821 modulation of process of another organism; GO:0042311 vasodilation; GO:0097746 blood vessel diameter maintenance
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  KLSGCFGFKLDRIGTMSGLGC
  • Length:  21
  • Propeptide:  KLSGCFGFKLDRIGTMSGLGC
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Scorpion venom natriuretic peptide that increases the perfusion pressure, glomerular filtration rate and urinary flow in the isolated perfused rat kidney assay. Induces a decrease of the percentages of renal transport for sodium, potassium and chloride and an increase of the urinary cGMP concentration. Also down-regulates the mRNA expression of natriuretic peptide receptor-A (NPR1) in the kidneys whereas it up-regulates those of NPR-B (NPR2), NPR-C (NPR3) and guanylyl cyclase C (GUCY2C) mRNAs. May exhibit hypotensive and vasodepressor activities.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  5-21
  • Structure ID:  AF-P0DMD6-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    AF-P0DMD6-F1.pdbhor005152_AF2.pdbhor005152_ESM.pdb

Physical Information

Mass: 254755 Formula: C95H156N26O27S3
Absent amino acids: AEHNPQVWY Common amino acids: G
pI: 8.82 Basic residues: 3
Polar residues: 10 Hydrophobic residues: 6
Hydrophobicity: 39.52 Boman Index: -886
Half-Life: 1.3 hour Half-Life Yeast: 3 min
Half-Life E.Coli: 2 min Aliphatic Index 74.29
Instability Index: 757.14 Extinction Coefficient cystines: 125
Absorbance 280nm: 6.25

Literature

  • PubMed ID:  23911732
  • Title:  Isolation, homology modeling and renal effects of a C-type natriuretic peptide from the venom of the Brazilian yellow scorpion (Tityus serrulatus).